Synergistic inhibition of human tumor growth in mice by combined treatment withHPMA copolymer-TNP-470 (caplostatin) and Avastin

机译：通过HPMA共聚物-TNP-470（caplostatin）和阿瓦斯汀的联合治疗，协同抑制小鼠体内人类肿瘤的生长

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The development of a vascular supply,angiogenesis, is a critical factor in the growth andmetastatic spread of malignant tumors. Here wepropose the combination of two novel angiogenesisinhibitors: HPMA copolymer-TNP-470 conjugate andAvastin, a humanized monoclonal antibody directedat VEGF. The combination had a synergistic effecton human tumors in mice.

机译：血管供应的发展，血管生成是生长和生长的关键因素恶性肿瘤转移扩散。在这里，我们提出两种新型血管生成的结合抑制剂：HPMA共聚物-TNP-470共轭物和 Avastin，一种定向的人源化单克隆抗体在VEGF。该组合具有协同作用在小鼠的人类肿瘤上。

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《Annual meeting exposition of the Controlled Release Society》|2005年|1-2|共2页
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Ronit Satchi-Fainaro; Amy E. Birsner; Sarah M. Short; Catherine Butterfield; Judah Folkman;
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中图分类药学;
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入库时间 2022-08-26 14:53:50

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专利

1. 53 INVITED HPMA copolymer-TNP-470 (caplostatin) and Avastin show synergistic inhibition of human tumor growth in mice [J] . European Journal of Cancer Supplements . 2005,第2期

机译：53个被邀请的HPMA共聚物-TNP-470（caplostatin）和Avastin在小鼠中显示出对人类肿瘤生长的协同抑制作用
2. Synergistic inhibition of tumor growth and metastasis by combined treatment with TNP-470 and gemcitabine in a human bladder cancer KoTCC-1 model. [J] . Muramaki M, Miyake H, Hara I, The Journal of Urology . 2004,第4aPta1期

机译：通过在人膀胱癌KoTCC-1模型中联合使用TNP-470和吉西他滨协同抑制肿瘤生长和转移。
3. Combination therapy with epigallocatechin-3-gallate and doxorubicin in human prostate tumor modeling studies: inhibition of metastatic tumor growth in severe combined immunodeficiency mice. [J] . Stearns ME, Amatangelo MD, Varma D, American Journal of Pathology: Official Publication of the American Association of Pathologists . 2010,第6期

机译：在人类前列腺肿瘤模型研究中与表没食子儿茶素-3-没食子酸酯和阿霉素联合治疗：在严重的联合免疫缺陷小鼠中抑制转移性肿瘤的生长。
4. Modeling of Tumor Growth Inhibition in Mice Following Electrochemotherapy [C] . T. Forjanic, D. Miklavcic World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food Environmental Technologies . 2016

机译：电化学疗法后小鼠肿瘤生长抑制的建模
5. Prolactin and isplatin combination treatment inhibit tumorspheres formation and tumor growth in mice [D] . Lee, Eric Hingleung 2013

机译：催乳素和异铂联合治疗可抑制小鼠肿瘤球的形成和肿瘤的生长
6. Inhibition of Epidermal Growth Factor Receptor and Vascular Endothelial Growth Factor Receptor Phosphorylation on Tumor-Associated Endothelial Cells Leads to Treatment of Orthotopic Human Colon Cancer in Nude Mice [O] . Takamitsu Sasaki, Yasuhiko Kitadai, Toru Nakamura, 2007

机译：表皮生长因子受体和血管内皮生长因子受体磷酸化对肿瘤相关内皮细胞的抑制作用导致裸鼠原位人类结肠癌的治疗
7. Combination Therapy with Epigallocatechin-3-Gallate and Doxorubicin in Human Prostate Tumor Modeling Studies : Inhibition of Metastatic Tumor Growth in Severe Combined Immunodeficiency Mice [O] . Stearns, Mark E., Amatangelo, Michael D., Varma, Devika, 2010

机译：联合治疗与Epigallocatechin-3-Gallate和阿霉素在人类前列腺肿瘤模型研究中的应用：严重联合免疫缺陷小鼠对转移性肿瘤生长的抑制作用

Synergistic inhibition of human tumor growth in mice by combined treatment withHPMA copolymer-TNP-470 (caplostatin) and Avastin

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