THERMOSENSITIVE POLY(PHOSPHAZENE) HYDROGELS FOR CELL DELIVERYSYSTEM

摘要

Thermosensitive poly(organophosphazene) gelsbearing -amino- -methyl-poly(ethylene glycol)(AMPEG) and hydrophobic L-isoleucine ethyl ester(IleOEt) side groups have been synthesized. A 10 wt%buffered solution of the polymer was employed to entrapcells in an cell delivery. Specific cells entrapped in the gelshowed prolonged cell viability compared to entrappedcells in other types of polymer gels. This thermo-sensitiveinjectable, biodegradable matrix can be used with severalcell types, including nerve cells to promote nerveregeneration.