Polymorphs of Fluconazole Recrystallized using the Solution Enhanced Dispersionby Supercritical Fluids (SEDS) Process

摘要

The purpose of this study was to investigate theinfluence of process valuables such as temperature,pressure, injection rate of drug solution, and solvent onthe polymorphism of fluconazole during SEDS process.The fluconazole after SEDS process was characterized byDSC, PXRD, and FT-IR. This SEDS technique wassuccessfully used to crystallize polymorphs offluconazole.