CONTROLLED RELEASE OF ASIATICOSIDE FROM CHITOSAN-ALGINATE MICROSPHERES CONTAINING Centella asiatica EXTRACT

摘要

Chitosan-alginate microspheres containing titrated extract of Centella asiatica (TECA) were prepared by complex coacervation/emulsification technique. The microspheres were monodisperse and the surface mean diameter varied according to oil types and addition of polyvinylpyrrolidone K-30 (PVP K-30). The SEM determination indicated the porous morphology of the microspheres. The release of asiaticoside (as a marker of TECA) from the microspheres in water at 37°C was controlled for 48 hours.