Time dependent entropy analysis of multiunit activity in the cortex following the hypoxic-ischemic brain injury

摘要

Previous study has shown that the scalp electrical activity (e.g. EEG) could provide information on hypoxic-ischemic (HI) brain injury. The time dependent entropy (TDE) of EEG was applied as a means to segment the injury and recovery phases. A reduction in entropy during the injury was explained as the result of the spiking or bursting activity during the recovery of HI injury. The aim of this study is to investigate the spiking activity in the cortex during (HI) brain injury. The multiunit activity recorded from the cortex (CTX MUA) is analyzed with TDE methods. The spike sensitive TDE tracks the electric activity at the cellular level. The CTX MUA has high TDE value after the HI injury, which gradually returns to the baseline level as the brain recovers. This is the first report of cellular electrical response to global ischemic injury.