Dissolution profiles of chloroquine tablets using a flow-through chloroquine sensor

摘要

A potentiometric polyvinyl chloride membrane comprising of bis(2-ethylhexyl)adipate as plasticizer and potassium tetrakis(4-chlorophenyl)borate was developed as a chloroquine sensor. The sensor was later applied as a detector in a flow injection analysis set up where it was not only successfully used in the determination of active ingredient in pharmaceutical preparations but also in establishing the dissolution profiles for chloroquine tablets. The flow through chloroquine sensor offers high accuracy and excellent repeatability, with large sample throughput (90 mL min/sup -1/). Besides being simple, the technique is rapid, low cost and allows direct quantification of chloroquine (without sample pretreatment).