Automatic adjustment of manually measured QT intervals in digital electrocardiograms improves precision of electrocardiographic drug studies

摘要

Drug investigation studies require similar patterns of T/U waves to be measured at the same fiducial points. However, such a systematic measurement is difficult to achieve with manual measurement as compulsory for regulatory review. A new system was developed that adjusts manually measured QT intervals in sets of ECGs obtained from the same drug study. For a given threshold w, the system organizes all the repolarisation patterns in groups of ECG leads that correlate each with each other with abs(r)0.002). The QT dispersion values were reduced from 38.3 (SD=172) to 30.2 (SD=15.4) ms (p>10/sup -200/). Automatic adjustment of manual measurements of QT intervals in electronically recorded ECGs improves the precision of QT interval assessment in electrocardiographic drug studies.