A system to monitor the subcutaneous tissue glucose concentration continuously and ex vivo with a portable device is presented. The method of open flow microperfusion was evaluated during hyperinsulinemic hypoglycaemic clamp experiments in 6 healthy volunteers. During these experiments good agreement (correlation coefficients 0.85-0.95, n=65-91) between blood glucoseand subcutaneous tissue glucose concentration could be observed. In conclusion, it could be shown that monitoring subcutaneous tissue glucose concentrations during hypoglycaemia is feasible with open flow microperfusion.
展开▼
