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Critical Review: Human Health Literature Related to Unconventional Oil and Natural Gas Development

机译:批评评论:与非常规石油和天然气开发有关的人类健康文献

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Background Development of oil and natural gas from unconventional resources (UOGD) has expanded rapidly in the last decade, and increased public and academic interest has led to a growing body of literature about its potential health effects. This review summarizes the epidemiological evidence and what the body of literature does and does not tell us about the relationship between UOGD and health. Methods The Health Effects Institute's Energy Research Committee (the Committee), consisting of multidisciplinary experts from across the U.S., along with HEI staff systematically reviewed the peer-reviewed and gray epidemiologic literature published between January 2000 and March 2018 by searching several electronic databases and consulting with expert stakeholders. The Committee elected to review analytical epidemiological studies worldwide with a primary focus on UOGD exposure and human health outcomes to assess whether the health of people living in locations affected by UOGD are adversely affected by the operations. Each study was assessed in duplicate for quality and risk of bias using an approach based on guidance from the National Toxicology Program Office of Health Assessment and Translation. Results The epidemiologic studies report associations between UOGD and various outcomes, including perinatal effects, asthma, cancer, hospitalizations and self-report health symptoms. Study authors discuss limitations of their studies, including reliance on imprecise proxies for UOG Exposure, with many noting that causality cannot be assessed without better exposure measures. This presentation will provide the Committee's findings about the strengths and weaknesses of this body of literature. Conclusions This systematic, impartial literature review will be useful to regulators, scientists, and others interested in understanding what is known about potential health effects of UOGD, what knowledge gaps remain, and how important knowledge gaps could be filled with future research.
机译:背景技术在过去的十年中,来自非常规资源(UOGD)的石油和天然气的发展迅速扩大,公众和学术界的兴趣日益浓厚,导致有关其潜在健康影响的文献越来越多。这篇综述总结了流行病学证据,以及有关UOGD与健康之间关系的文献资料做了什么,却没有告诉我们。方法健康影响研究所的能源研究委员会(委员会)由来自美国各地的多学科专家以及HEI员工组成,通过搜索多个电子数据库和咨询系统地回顾了2000年1月至2018年3月之间发表的经过同行评审的灰色流行病学文献与专家利益相关者。委员会选择审查全世界的流行病学分析研究,主要侧重于UOGD暴露和人类健康结果,以评估居住在受UOGD影响的地区的人们的健康是否受到手术的不利影响。使用基于国家毒理学计划健康评估和翻译办公室指导的方法,对每项研究进行一式两份的质量和偏倚风险评估。结果流行病学研究报告了UOGD与各种结局之间的关联,包括围产期影响,哮喘,癌症,住院和自我报告健康症状。研究作者讨论了他们研究的局限性,包括对UOG暴露的不精确代理的依赖,许多人指出,如果没有更好的暴露措施,就无法评估因果关系。本演讲将提供委员会关于该文献体系优缺点的调查结果。结论这项系统,公正的文献综述对监管者,科学家和其他有兴趣了解UOGD潜在健康影响的知识,尚存在哪些知识空白以及将来的研究如何填补重要知识空白的人士很有用。

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