FLUORESCENT RATIOMETRIC THERMOMETER WITH ENHANCED SENSITIVITY FROM L-TRYPTOPHAN-LABELED POEGMA MICROGELS AND QUINOLINE/ZN2+-LABELED THERMOSENSITIVE PEG-B-PMEO2MA BLOCK COPOLYMERS

摘要

@@Sensitive detection of temperature is of vital importance to our daily lives and scientific research. Among various methods utilized to measure temperatures, fluorescence-based thermosensitive devices or fluorescent thermometers possess unique advantages such as applicable in microsized domains (e.g., cells and tissues) and harsh environments (e.g., high voltage).1 Fluorescent thermometers are classified into three main types: the first type shows heat-induced fluorescence enhancement, the second type shows heat-induced fluorescence quenching, and the third one shows selective emission enhancement at a specific temperature range.2 However, for all three detection types, the detection sensitivity and reliability are quite limited due to the fluorescence intensity-based detection principle, which are inherently subjected to interferences from the detection background.