BIODISTRIBUTION OF POLY (LACTIC- CO-GLYCOLIC) ACID (PLGA) AND PLGA/CHITOSAN NANOPARTICLES IN F344 RATS ORALLY EXPOSED TO NANOPARTICLES FOR SEVEN DAYS

摘要

1. Following repeat-dose administration, PLGA NPs reached liver, spleen, kidney, tteart, lung, and brain, with highest concentrations (%dose/g) in the spleen, intestine, kidney, and lung 2. NP concentration in brain and heart measured the lowest concentrations 3. A maximum of 46.1% PLGA and 41.1 % PLGA/chi of daily dose or 6.6% PLGA and 5.9% PLGA/chi of total dose was recovered after 7 days of daily gavage with 3 mg NPs/dose. 4. For oral delivery, NP concentrations are much smaller than NP concentration rn the same tissue for IV treated animals 5. Biodistribution of PLGA and PLGA/Chi were not significantly different.