Advanced Multi-objective Design Analysis to Identify Ideal Stent Design

摘要

Coronary stents are the preferred option for treating diseased coronary arteries. When implanted, the stent is deployed at the lesion to restore the lumen area by scaffolding the vessel open. However, stents still have a relatively high failure rate of 2-8%, with many patients requiring further interventions due to restenosis and stent thrombosis. It is known that blood flow disruption caused by the presence of a stent can trigger signalling pathways that accelerate restenosis or trigger thrombus formation. This work aims to find design variable values that minimize these adverse flow conditions using Multi-Objective optimisation.