ASSOCIATION BETWEEN AGENT ORANGE EXPOSURE AND CANCER INCIDENCE AMONG KOREAN VIETNAM WAR VETERANS USING EXPOSURE OPPORTUNITY INDEX MODEL : KOREAN VIETNAM WAR VETERANS COHORT STUDY

摘要

A total of 320 thousand Korean soldiers of three combat units and four supporting units participated in Vietnam War. The aim of this study was to investigate association between Agent Orange exposure and cancer incidence in Korean Vietnam War veterans. Agent Orange exposure was estimated using exposure opportunity index model by Stellman. A total of 153,463 veterans was included for analysis. The numbers of low and high exposure group were 74,978 and 78,485, respectively. Indirectly standarized incidence ratio(ISIR), and ratio of indirectly standardized incidence ratio (RISIR) by exposure group and 95% confidence interval was calculated using exact method. Cancer incidence of all sites of cancer was not significantly associated with Agent Orange exposure. High exposure group had increased risks of lip and oral cavity cancer(RISIR=1.87, 95% CI: 1.13-3.18), and chronic myeloid leukemia(RISIR=2.56, 95% CI=0.88-8.99, p=0.092) with a borderline significance. Agent Orange exposure was not associated with the incidences of Hodgkin's disease, non-Hodgkin's lymphoma, lung cancer, laryngeal cancer and multiple myeloma.