Establishment of Treatment of Retinal Vein Occlusion by Physical Stimuli of Electrically-Induced Bubbles

摘要

For this study, a novel treatment of retinal vein occlusion by physical stimuli of electrically-induced bubbles was proposed. Our device can apply local and minimally-invasive physical stimuli to retinal minute blood vessels with a diameter of about 100 μm, utilizing the impact pressure when microbubbles collapse. Furthermore, it is possible to sense the approach of the device to the target by measuring the capacitance. Vascular vessels of chick embryos whose size is similar to that of the retinal vein, and retinal veins of pig were used as in-vitro and in-vivo model respectively. Also, micro-vascular occlusion models were successfully operated and local physical stimuli was applied to the blood clot which is artificially produced. The 60% of reperfusion against the initial amount was confirmed by blood flow measurement for both in vitro and in vivo environment.