Label-Free Real-Time Imaging of Extracellular Lactate From a Hippocampal Slice Based on Charge-Transfer-Type Potentiometric Redox Sensor Arrays

摘要

Medically important real-time imaging of extracellular lactate and its spatiotemporal analysis has not yet been achieved. If it could be successfully realized, it would help clarify the function of physiological neurotransmission and drug discovery based on glial cell neuron lactate transport. To this end, we fabricated a 40 μm pitch, 128 × 128 pixel redox-type label-free lactate image sensor based on a potentiometric hydrogen peroxide (H