DNA Aptamer-Linked Structural-Color Hydrogel for Repeatable Biochemical Sensing

摘要

This paper describes a DNA aptamer-linked structural-color hydrogel sensor that can quantitatively and repeatably detect biochemical substances through visual information without any specific equipment. The initial color of structural-color hydrogel could be adjusted by controlling the concentration of the colloidal silica particle. We co-polymerized a DNA aptamer that specifically binds to silver ions into acrylamide hydrogel and evaluated its quantitative shrinking response to silver acetate solution. In addition, we succeeded in initializing our DNA aptamer hydrogel sensor by heating, indicating that our chemical sensor could repeatably measure the target chemical substance for the long term. We believe that our structural-color biochemical sensor could be applied to various routine monitoring such as healthcare diagnosis and water safety.