Non-disjoint Clustered Representation for Distributions over a Population of Cells

摘要

We consider a large homogenous population of cells, where each cell is governed by the same complex biological pathway. A good modeling of the inherent variability of biological species is of crucial importance to the understanding of how the population evolves. In this work, we handle this variability by considering multivariate distributions, where each species is a random variable. Usually, the number of species in a pathway -and thus the number of variables- is high. This appealing approach thus quickly faces the curse of dimensionality: representing exactly the distribution of a large number of variables is intractable.