Surviving Gene Expression and Progression of Cervical Intraepithelial Neoplasia: A Systematic Review with Meta-Analysis

摘要

The relationship between survivin expression and Cervical Intraepithelial Neoplasia (CIN) remains controversial. We evaluate the potential role of survivin in tumorigenesis and progression of CIN. Related articles were searched of PubMed, EMBASE, pmc, sciencederaction library, Wanfang, VIP, CNKI from January 2002 to May 2012. Meta-Analyst Beta 3.13 was applied to pool eligible studies and summary odds ratio (OR). We performed a final analysis of 717 patients from 9 studies. Combined OR of CIN1-2 and CIN2-3 suggests that survivin expression becomes higher with disease progression (OR = 3.117, 95% CI: 1.797-5.409, P