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Whole-Genome Sequencing to Determine Origin of Diarrhea in Suckling Piglets in Southern China

机译:全基因组测序确定中国南方乳猪腹泻的起源

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Severe diarrhea in suckling piglets occurred in southern China in 2017 and a new porcine coronavirus, named as porcine enteric alphacoronavirus (PEAV), was identified. Here we reported a detailed process to sequence, assemble and analyze the whole genome of PEAV. GDS04 has 87% amino acid identity comparing to the S proteins of the HKU2 strains without recombination, and their receptor-binding domains in S protein differ at 20 amino acids, suggesting that GDS04 could be a new mutant virus from bat-like CoVs and responsible for the most recent diarrhea endemic in pig herds in southern China.
机译:2017年,中国南部的乳猪仔出现严重腹泻,并发现了一种新的猪冠状病毒,称为猪肠α冠状病毒(PEAV)。在这里,我们报告了一个详细的过程,以测序,组装和分析PEAV的整个基因组。与未经重组的HKU2菌株的S蛋白相比,GDS04具有87%的氨基酸同一性,并且它们在S蛋白中的受体结合结构域在20个氨基酸处存在差异,这表明GDS04可能是蝙蝠状冠状病毒中的一种新突变病毒,并且可以是中国南方猪群最近一次的腹泻流行病。

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