Preparation and Characterization of Coenzyme Q_(10)-loaded Nanostructured Lipid Carriers

摘要

The enhancement of stability of light sensitive CoQ_(10) was achieved by preparation of coenzyme Q_(10)-loaded Nanostructured Lipid Carriers through High Pressure Homogenization (HPH). Well-dissolved lipids of CoQ_(10) were selected, optimized ratio of emusifiers and lipids were determined for the formulation. Obtained by photon correlation spectroscopy (PCS), the mean particle size of CoQ_(10)-NLC was 112 ± 7 nm within 60 days after preparation. In terms of centrifugal stability, results of laser diffraction (LD) analysis eliminated the existence of aggregated particles with micrometers and showed almost no size growth before and after centrifugation. Zeta potential values were from -50 to -55 mV with pH in the range of 6.56-6.72. The concentration of CoQ_(10)-NLC measured by UV-Vis spectroscopy was as high as 8.13 mg/mL.