Self-Disinfecting Urinary Biomaterials: pH-Triggered Quinolone Release for Prevention of Catheter-Associated Urinary Tract Infections

摘要

The observed increase in quinolone bactericidal activity in alkaline conditions provides rational for their use in the chemotherapy of urinary tract infections. Initial microbiological assessment suggests that the pH-responsive nalidixic acid conjugate copolymers developed herein hold significant promise for preventing CAUTIs when applied as urinary catheter coatings.