The development of an artificial, biodegradable nerve guide

摘要

Summary form only given. Over a period of approximately ten years, a biodegradable nerve guide was developed at the University of Groningen (The Netherlands). It comprised the combined research of the departments of Polymer Chemistry, Medical Physiology, Medical Biology, Pathology and Plastic Surgery. At first a polymer was developed and tested. A prototype tube was then used in an animal model (rat sciatic nerve) to establish axonal regeneration short-term and long-term. At the same time cytotoxicity and biocompatibility tests of the polymer were conducted. Once the axonal regeneration and safety of this material were proven, a functional outcome study was performed using several parameters (walking track analysis, withdrawal reflex) to monitor sensory and motor function recovery. We are now at a stage were a clinical pilot study will be initiated to find clinical regeneration of short nerve defects. Future research will be directed towards faster regeneration as well as the bridging of longer gaps using tissue engineered devices. The whole process of integrating this research will be discussed.