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Cellulat

机译:蜂窝电话

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In order to model the cell it is essential to understand the communication system that governs its behaviour. Though it is true that determining the kinetic equations of the biochemistry involved in vital functions is very useful, the management of the information in order for the cell to make the correct physiological decisions is even more so. This can be appreciated in the determinacy of the correct function of oncogenes coding for signal transduction components. We emulate a signal transduction network using behaviour-based systems and the blackboard architecture. Our construct, named Cellulat, allows one to observe two essential aspects of the intracellular signalling networks: (1) the apparent behavioural capabilities and (2) a spatial organization. The first user interfaces for creating a model cell are presented, the ontology used, as well as a simple example for the analysis of a kinase pathway.
机译:为了对单元建模,必须了解控制其行为的通信系统。虽然确定参与生命机能的生物化学动力学方程是非常有用的,但为了使细胞做出正确的生理决定而对信息进行的管理就更为有用。在确定编码信号转导成分的致癌基因的正确功能中可以认识到这一点。我们使用基于行为的系统和黑板架构来模拟信号转换网络。我们的名为Cellulat的构建体可以观察细胞内信号网络的两个基本方面:(1)明显的行为能力和(2)空间组织。介绍了用于创建模型单元的第一个用户界面,使用的本体以及用于分析激酶途径的简单示例。

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