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首页> 外文会议>Controlled Release Society annual meeting >Novel Lactosylated Poly(ethylene glycol)–Oligodeoxynucleotide Conjugate through Acid-Labile Linkage for pH-Responsive Receptor-TargetedOligodeoxynucleotide Delivery System
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Novel Lactosylated Poly(ethylene glycol)–Oligodeoxynucleotide Conjugate through Acid-Labile Linkage for pH-Responsive Receptor-TargetedOligodeoxynucleotide Delivery System

机译：新型的乳酸化聚乙二醇-寡聚脱氧核苷酸通过酸不稳定的键结合，用于pH敏感受体靶向的寡聚脱氧核苷酸递送系统

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摘要

An oligodeoxynucleotide conjugated to lactosylated poly(ethyleneglycol) through an acid-labile linkage (Lac-PEG-ODN) wassuccessfully synthesized to form PIC micelles with poly(L-lysine)(PLL). The Lac-PEG-ODN/PLL PIC micelles exhibited highlyantisense activity (about 65% inhibition) due to the increase in thecellular uptake and release of free ODN into cytosol. Type in texthere making sure it is in a two-column format.
机译：通过酸不稳定键（Lac-PEG-ODN）成功合成了与乳糖基化聚乙二醇偶联的寡脱氧核苷酸，从而与聚（L-赖氨酸）（PLL）形成了PIC胶束。 Lac-PEG-ODN / PLL PIC胶束由于细胞摄取的增加和游离ODN释放到细胞质中而表现出高度反义活性（抑制约65％）。在此处输入文本，以确保其为两列格式。

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  • 会议地点 Honolulu, HI(US)
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    Motoi Oishi; Shigeki Sasaki; Yukio Nagasaki; Kazunori Kataoka;

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    Department of Materials Science and Technology Tokyo University of Science 2641 Yamazaki Noda Chiba 278-8510 Japan CREST Japan Science and Technology Agency [JST] Tokyo Japan;

    Graduate School of Pharmaceutical Science Kyushu University 3-3-1 Maidashi Higashi-ku Fukuoka 812-8582 Japan CREST Japan Science and Technology Agency [JST] Tokyo Japan;

    Department of Materials Science and Engineering Graduate School of Engineering The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8656 Japan CREST Japan Science and Technology Agency [JST] Tokyo Japan;

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