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A Ticking Clock: Performance Analysis of a Circadian Rhythm with Stochastic Process Algebra

机译:滴答时钟:带有随机过程代数的昼夜节律性能分析

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We apply performance analysis techniques to a biological modelling problem, that of capturing and reproducing the Circadian rhythm. A Circadian rhythm provides cells with a clock by which to regulate their behaviour. We consider two distinct stochastic models of the Circadian rhythm - one unbounded and the other bounded. We consider a fluid approximation of the models, and, by conversion to a set of ordinary differential equations, we are able to reproduce the correct rhythm. We show that with a bounded model, the clock phase can be affected by modifying the ability to manufacture some proteins.
机译:我们将性能分析技术应用于生物学建模问题,即捕获和再现昼夜节律的问题。昼夜节律为细胞提供时钟以调节其行为。我们考虑了昼夜节律的两个不同的随机模型-一个是无界的,另一个是有界的。我们考虑模型的流体近似,通过转换为一组常微分方程,我们能够重现正确的节奏。我们表明,使用有界模型,可以通过修改制造某些蛋白质的能力来影响时钟相位。

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