The efficiency of fiber optical tweezers for cell manipulation using distinct fabrication methods

摘要

In this work, the trapping efficiency of new fiber optical tweezers structures fabricated using photo polymerization and focused ion beam milling techniques is evaluated. The first fabrication methods may present limited capabilities on the tailoring of the structures, and therefore limited operation features. On the other hand, with focused ion beam milling a vast myriad of structures may be accurately fabricated, and contrarily to conventional fabrication methods, more specialized manipulation tools can be developed. In this regard, the performance of FOT for the trapping of yeast cells using spherical lenses (photo polymerization) and spiral phase lenses (FIB) will be presented. In addition, finite difference time domain (FDTD) simulations of the full vectorial optical propagation through the designed structures and the corresponding calculation of the optical forces are presented and different designs are evaluated.