Studies on the Influence of Scleraldehyde on Stabilization of Collagen

摘要

The present study investigates on the stabilization of collagen was crosslinked with scleraldehyde. Schizophyllan is a natural polysaccharide, produced by fungi of the genus Schizophyllum. Periodate oxidation specifically cleaves the vicinal glycols in scleraldehyde to form their dialdehyde derivatives. The formation of the crosslinked network between scleraldehyde and the collagen fibres has brought about significant thermal and enzymatic stability to collagen. Scleraldehyde crosslinked collagen fibres exhibited an increase in hydrothermal stability by 18oC with scleraldehyde at pH 8. Thermal stability and crosslin king efficiency was found to increase with pH and concentration of scleraldehyde.