A Method for Preparing High Purity L-Alpha Glyceryl-phosphorylethanolamine

摘要

甘油磷脂酰乙醇胺(L-α-Glycerylphosphorylethanolamine,L-α-GPE)被证明具有治疗老年性智力衰退、遗传和非遗传性脑血管疾病,以及治疗精神活动迟缓、记忆力下降、情绪波动和情感脆弱等综合症的潜力.由于这些应用价值,已被广泛应用到医药和食品添加剂行业.天然的L-α-GPE主要存在于肝、脾、肾和牛脑等器官当中,但含量比较少.因此,建立制备高纯度L-α-GPE生产技术将具有重要的医药、社会、经济和研究价值.它的主要传统制备方法:生物原料萃取、烯醛磷脂水解、化学合成、蛋黄或大豆磷脂醇解,但是这些技术在得率、纯度及环境污染等方面面临着不同程度的问题.%L-α-Glycerylphosphorylethanolamine (L-α-GPE) has been shown to have potential for the treatment of senile cerebral alteration,of both involutive and cerebro-valcular insufficiency origin,and of the related symptomatology,such as slowing of psychic activity,memory decrease,mood alteration,emotional weakness,etc.These potential,valuable uses for L-α-GPE have prompted exploration into its possible use as a medicinal applications and food additive,but it occurs naturally as only a trace compound and mainly presence in the liver,spleen,kidney and brain of oxen,and thus research into the production of high-purity of L-α-GPE would have important medicinal,social,economic,and research value.L-α-GPE previously obtainable by the extraction of biological material,the catalytic hydrolysis of plasmalogen,chemical synthesis and alcoholysis from egg or soy lecithin.