Corneal nerves segmentation and morphometric parameters quantification for early detection of diabetic neuropathy

摘要

Morphological parameters of the corneal sub-basal nerve plexus may be the basis of a simple and noninva-sive method for detection and follow-up of diabetic neuropathy. These nerves can be analyzed from images obtained in vivo by corneal confocal microscopy. In this work we present and evaluate an automatic methodology capable of identifying corneal nerves and determine various morphometric parameters.