DNA G-quadruplexes as potential drug targets

机译：DNA G-四链体作为潜在的药物靶标

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摘要

The DNA G-quadruplex secondary structures have been demonstrated as potential regulatory elements in regions of biological significance,such as in human telomeres and in the promoters regions of a number of important growth-related genes.

机译：已经证明DNA G-四链体二级结构是具有生物学意义的区域中的潜在调控元件，例如在人类端粒和许多重要的与生长相关的基因的启动子区域中。

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来源
《The 12th International Beijing Conference and Exhibition on Instrumental Analysis : Conference Abstracts》|2007年|1|共1页
会议地点 Beijing(CN)
作者
Danzhou Yang;
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作者单位

College of Pharmacy,University of Arizona,1703 E.Mabel St,Tucson,AZ 85721;

Arizona Cancer Center,1515 N.Campbell Avenue,Tucson,AZ 85724;

BIO5 Institute,University of Arizona,1140 E.South Campus Dr,Tucson,AZ 85721;

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原文格式 PDF
正文语种 eng
中图分类仪器、仪表;化学;
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专利

1. DNA G-quadruplexes, telomere-specific proteins and telomere-associated enzymes as potential targets for new anticancer drugs. [J] . Raymond E, Soria JC, Izbicka E, Investigational new drugs. . 2000,第2期

机译：DNA G四联体，端粒特异性蛋白和端粒相关酶是新抗癌药物的潜在靶标。
2. Drug discovery targeting epigenetic codes: the great potential of UHRF1, which links DNA methylation and histone modifications, as a drug target in cancers and toxoplasmosis. [J] . Unoki M, Brunet J, Mousli M Biochemical Pharmacology . 2009,第10期

机译：针对表观遗传密码的药物发现：UHRF1具有巨大的潜力，可将DNA甲基化和组蛋白修饰联系起来，成为癌症和弓形虫病的药物靶标。
3. Amplified Chemiluminescence Detection of DNA by Strand-Displacement Polymerization Target Recycling and G-quadruplexes/Hemin DNAzyme Catalysis [J] . Limin Zhao, Yong Huang, Liangliang Zhang, Plasmonics . 2014,第5期

机译：通过链置换聚合靶回收和G-四链体/血红素DNA酶催化扩增DNA的化学发光检测
4. DNA G-quadruplexes as potential drug targets [C] . Danzhou Yang International Beijing Conference and Exhibition on Instrumental Analysis . 2007

机译：DNA G-quadruprys作为潜在的药物靶标
5. An in Silico Study of Small Molecule Anti-cancer Agents Targeting DNA G-Quadruplexes [D] . Sullivan, Holli-Joi. 2020

机译：一种靶向DNA G-四链分子的小分子抗癌剂的硅研究
6. G-Quadruplexes as Potential Therapeutic Targets for Embryonal Tumors [O] . Tarek Shalaby, Giulio Fiaschetti, Kazuo Nagasawa, 2013

机译：G四联体作为胚胎肿瘤的潜在治疗目标。
7. Targeting destabilized DNA G-quadruplexes and aberrant splicing in drug-resistant glioblastoma [O] . Deanna M Tiek, Roham Razaghi, Lu Jin, 2019

机译：靶向不稳定的DNA G-四链和耐药胶质母细胞瘤中的异常剪接

DNA G-quadruplexes as potential drug targets

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