The present invention relates to serotypes 1, 2, 5, 7, 10, 12 and 15 among various serotypes of porcine pleurisy, APP type 1, 2, 5, 7, It relates to a vaccine composition for the prevention or treatment of pleural pneumonia in pigs comprising the inactivated dead cells of type 10, type 12 and type 15 as an active ingredient. The present invention relates to GI24, chlorhexidine digluconate (Chlorhexidine digluconate or Chlorhexidine digluconate solution) or chlorhexidine after culturing pig pleural pneumonia-derived serotype 1, 2, 5, 7, 10, 12 and 15 strains. In piglets vaccinated by mixing inactivated dead cells such as live cells treated with diacetate (Chlorhexidine acetate or Chlorhexidine diacetate or Chlorhexidine diacetate salt hydrate), etc. APP type 1 to type 15 strain) was confirmed. Therefore, the mixture of inactivated dead cells such as live cells of the present invention is expected to be usefully used as a vaccine for prevention and treatment of porcine pleural pneumonia that can be safely, economically and conveniently inoculated.
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