首页> 外国专利> Pharmaceutical Composition for Enhancing Anti-Cancer Effect of Immune Checkpoint Inhibitors Comprising Glutamine Transporter Inhibitor as an Active Ingredient

Pharmaceutical Composition for Enhancing Anti-Cancer Effect of Immune Checkpoint Inhibitors Comprising Glutamine Transporter Inhibitor as an Active Ingredient

机译:用于增强免疫检查点抑制剂的抗癌作用的药物组合物作为谷氨酰胺转运蛋白抑制剂作为活性成分的免疫检查点抑制剂

摘要

The present invention relates to a pharmaceutical composition for enhancing the anticancer effect of an immune checkpoint inhibitor, including as an active ingredient using a glutamine transporter inhibitor, wherein the composition according to the present invention exhibits the activity of T cells in the anticancer action by the immune checkpoint inhibitor. By increasing and increasing the infiltration response of T cells in the tumor, it is possible to significantly enhance the anticancer effect. Therefore, the composition of the present invention can be usefully used as a pharmaceutical composition for treating various cancer patients, including cancer patients who do not show a therapeutic effect by only administering the conventional immune checkpoint inhibitor alone.
机译:本发明涉及一种用于增强免疫检查点抑制剂的抗癌效果的药物组合物,包括使用谷氨酰胺转运蛋白抑制剂作为活性成分,其中根据本发明的组合物在抗癌剂中表现出T细胞的活性 免疫检查点抑制剂。 通过增加和增加肿瘤中T细胞的渗透响应,可以显着提高抗癌效果。 因此,本发明的组合物可以用作治疗各种癌症患者的药物组合物,包括仅通过单独施用常规免疫检查点抑制剂而没有显示治疗效果的癌症患者。

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