Evaluation of intestinal barrier function to improve treatment of inflammatory bowel disease

摘要

Evaluation of intestinal barrier function to improve the treatment of inflammatory bowel disease.In some embodimentsThe present invention relates toA method of identifying beneficial drugs to treat patients with inflammatory bowel disease: (a) determining the condition of the intestinal barrier in patients;Includes (b) classifying states into severe functional impairments or moderate dysfunctionPatients classified as having severe dysfunctionIdentified as patients expected to benefit from treatment with drugs selected from the group consisting of anti TNF agents and / or anti-IL-12 / 23 drugsPatients classified as having moderate dysfunctionAnti integrin agentAnti janustokinaseIdentified as patients expected to benefit from treatment with / or sphingosine-1-phosphate receptor agonistsProvide a method.No selection