KIDNEY ORGANOIDS HAVING NEPHROTOXICITY INDUCED BY TACROLIMUS AND PREPARATION METHOD THEREFOR

摘要

The present invention relates to kidney organoids having induced nephrotoxicity obtained by the treatment of kidney organoids, differentiated from stem cells, with tacrolimus as a calcineurin inhibitor, and to a preparation method therefor. The kidney organoids having induced nephrotoxicity of the present invention exhibit similar nephrotoxicity to in-vivo models, and thus are expected to be usable as an effective in-vitro model to investigate pathogenic pathways.