CRYβB2 PREDICTS POOR BREAST CANCER OUTCOME AND SENSITIZES TUMORS TO NUCLEOLIN AND CDK INHIBITION

摘要

CΚΥβΒ2 induces EMT, sternness, protein synthesis and cell cycle progression through regulation of nucleolin, contributing to an increase in tumor growth and metastasis. CΚΥβΒ2 can be used as a prognostic marker in African American women with TNBC. CΚΥβΒ2 can further select patients with TNBC and ER positive tumors that will likely benefit from inhibitors of ribosomal RNA synthesis, CDK4 and nucleolin.