A method for improving the prediction accuracy of human plasma concentrations using a biodynamic prediction software

摘要

Problem to be solved: to provide a method to improve the prediction accuracy of the human plasma concentration in the oral plasma by combining the parameters obtained in the in vitro test with the biodynamic prediction software.A method for predicting the concentration of a human ingested compound in a human plasma using a biodynamic prediction software.It is preferable that the cell test is a membrane permeability test using the human intestinal epithelial cell.Furthermore, it is preferred that the above described human intestinal epithelial cells are Caco-2 cells derived from human colon adenocarcinoma.Diagram