USE OF ANTI-BASIGIN HUMANIZED ANTIBODY FOR PREPARING MEDICAMENT FOR TREATING NOVEL CORONAVIRUS PNEUMONIA

摘要

Disclosed is use of an anti-human BASIGIN humanized antibody for preparing a medicament for treating novel coronavirus pneumonia. The anti-human BASIGIN humanized antibody has an amino acid sequence of a light chain variable region as shown in SEQ ID NO: 1 and an amino acid sequence of a heavy chain as shown in SEQ ID NO: 3. The nucleotide sequence of the light chain variable region is the sequence as shown in SEQ ID NO: 2, and the nucleotide sequence of the heavy chain variable region is the sequence as shown in SEQ ID NO:4. The antibody can specifically recognize and bind to host epithelial cell co-receptor CD147 which the virus invades, blocks the interaction of CD147 with coronavirus S protein and CD147 with cyclophilin A (CyPA), thereby inhibiting coronavirus from infecting host cells.