The invention is a method of exploiting hydrocarbons within a sedimentary basin, by stratigraphic simulation coupled with a hydrologic model and a diagenetic model. A gridded representation of the basin, comprising at least a mineralogical composition and a porosity within each cell, is determined by means of a stratigraphic simulator for at least one time step. Then, at least one hydrologic zone is delimited using a hydrologic model, and at least one chemical composition of the fluids and a direction of circulation of the fluids are determined in each cell located in the zone. At least the chemical composition of the fluids, the mineralogical composition and the porosity are then updated in each cell of the gridded representation with a diagenetic model comprising a hydrologic flux balance, established using at least the directions of circulation of the fluids and from which a cell visiting order is determined for the fluids.
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