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CD49F PROMOTING PROLIFERATION, MULTIPOTENCY AND REPROGRAMMING OF ADULT STEM CELLS THROUGH PI3K/AKT/GSK3 PATHWAY
CD49F PROMOTING PROLIFERATION, MULTIPOTENCY AND REPROGRAMMING OF ADULT STEM CELLS THROUGH PI3K/AKT/GSK3 PATHWAY
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机译:CD49F通过PI3K / AKT / GSK3途径促进成人干细胞的增殖,多能率和重编程
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摘要
The present invention relates to a method for obtaining adult stem cells, which have a surface antigen of CD49f, excellent formation of spheres due to sphere formation and high expression of OCT4 and SOX2, from a cell source including stem cells, and a cell therapeutic agent containing adult stem cells obtained by the method or cells differentiated therefrom as an active ingredient. According to the present invention, adult stem cells derived from spheres are suitable for mass culture of adult stem cells because of more rapid growth thereof compared with stem cells obtained by a known adhesive culture method, have a specific surface antigen so as to be homogeneously obtained by using the specific surface antigen, and are useful for preparing a cell therapeutic agent using the same because of excellent differentiation thereof.
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