Mutant and genetically modified filamentous fungal strains comprising an improved protein productivity phenotype and methods thereof

摘要

The present strains and methods of the present invention are directed to genetic modification in filamentous fungi to produce variant strains of filamentous fungi comprising an improved protein productivity phenotype. More specifically, as presented, described and exemplified herein, these variant strains of filamentous fungi comprising an improved protein productivity phenotype are well suited for growth in immersion cultures, such as in large-scale production of proteins of interest for commercial applications. Do.