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PARASPECKLE COMPONENT 1 (PSPC1) PROMOTING EPITHELIAL-MESENCHYMAL TRANSITION, STEMNESS AND METASTASIS AS AN ANTI-CANCER TARGET
PARASPECKLE COMPONENT 1 (PSPC1) PROMOTING EPITHELIAL-MESENCHYMAL TRANSITION, STEMNESS AND METASTASIS AS AN ANTI-CANCER TARGET
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机译:paraSpeckle组分1(pspc1)促进上皮 - 间充质转变,茎和转移作为抗癌目标
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摘要
An isolated nucleic acid encoding a C-terminal fragment of paraspeckle component 1 (PSPC1) is disclosed. The C-terminal fragment of the PSPC1 comprises an extension of more than 10 but no greater than 131 amino acid residues with its C-terminal amino acid identical to the C-terminus of the PSPC1 sequence SEQ ID NO: 3 and exhibits a biological activity against tumor cells. The tumor cells are associated with either PSPC1 or protein tyrosine kinase 6 (PTK6), or both. The anti-tumor activity is at least one selected from the group consisting of: (a) suppressing tumor cell growth; (b) suppressing tumor cell progression; (c) suppressing tumor cell metastasis; (d) decreasing PSPC1 expression; and (e) decreasing oncogenic PTK6 expression in cytoplasm. Also disclosed is a peptide comprising a C-terminal fragment sequence of PSPC1. A reagent kit and method for predicting tumor progression, metastasis, and prognosis in a cancer patient are also disclosed.
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机译:公开了编码ParaSpecle组分1(PSPC1)的C末端片段的分离的核酸。 PSPC1的C-末端片段包括大于10但不大于131个氨基酸残基的延伸,其C-末端氨基酸与PSPC1序列SEQ ID NO:3的C-末端相同,并表现出生物活性针对肿瘤细胞。肿瘤细胞与PSPC1或蛋白酪氨酸激酶6(PTK6)或两者有关。抗肿瘤活性至少是选自:(a)抑制肿瘤细胞生长; (b)抑制肿瘤细胞进展; (c)抑制肿瘤细胞转移; (d)减少PSPC1表达; (e)减少细胞质中的致癌PTK6表达。还公开了包含PSPC1的C-末端片段序列的肽。还公开了一种试剂盒和用于预测肿瘤进展,转移和预后的方法。
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