CD206+ MACROPHAGE-SPECIFIC MOLECULAR IMAGING PROBE COMPOSITIONS AND METHODS AND THE NONINVASIVE QUANTIFICATION OF ARTERIAL WALL MACROPHAGE INFILTRATION IN HUMANS

摘要

Described herein are compositions and methods for diagnosing, imaging, and quantifying non-calcified atherosclerotic plaque. Embodiments of compositions described herein comprise mannosylated dextran compounds along with other carbohydrate molecules comprising, for example, a diagnostic agent and a diagnostic moiety. The compounds and methods embodied herein produce superior localization and results for imaging, anatomically locating, and quantifying non-calcified atherosclerotic plaque.