A process for the production of a 6-p-hydroxyphenyl- α- (4-oxo-4h-thiopyran-3-ylcarboxamido) -acetic acid penicillanic acid of the formula: ** (see formula) ** And its non-toxic pharmaceutically acceptable salts, which process consists in reacting a 6-aminopenicillanic acid derivative represented by the formula: ** (see formula) ** Where r represents a hydrogen atom, an alkali metal atom or a residue etc. An organic ester that can be separated under mild conditions, or an ester thereof, with an acetic acid α -p-hydroxyphenyl- α-( 4-oxo-4h-thiopyran-3-yl-carboxamido), represented by the formula : ** (see formula) ** Or a reactive derivative thereof, and, if the r group is a residue of an organic ester that can be separated under mild conditions, separate said group. (Machine-translation by Google Translate, not legally binding)
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