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platinadiaminkomplexer foerfarande foer deras framstaellning foerfarande foer framstaellning av i medici under anvaendande av i dylik platinadiaminkomplex foer behandling av cancer samt saolunda framstaelld medici
platinadiaminkomplexer foerfarande foer deras framstaellning foerfarande foer framstaellning av i medici under anvaendande av i dylik platinadiaminkomplex foer behandling av cancer samt saolunda framstaelld medici
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机译:铂二胺配合物的制备方法使用此类铂二胺配合物的制备药物的方法,用于治疗癌症和由此制备的药物
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摘要
This invention relates to novel platinum-diamine complexes having the formula: IMAGE (1) wherein R1 and R2 independently of each other may be selected from the group consisting of hydrogen, an alkyl group having 1-20 carbon atoms, a cycloalkyl group having from 3-7 carbon atoms in the ring, an aralkyl group, and an aryl group having 1-20 carbon atoms, whereas R1 and R2 together may form a cycloalkyl group having 3-7 carbon atoms in the ring and having the formula: IMAGE (1a) wherein N is 2 to 7 and wherein R3 and R4 independently of each other are selected from the group consisting of hydrogen, an alkyl group having 1-20 carbon atoms, an aryl group or an aralkyl group having 1-20 carbon atoms in the alkyl group and X is an anionic group, providing that when X is either chlorine or malonate, R1, R2, R3 and R4 are not each H; when X is chlorine and R1 and R2 are each H, R3 and R4 are not each methyl; when X is chlorine and R1 and R2 are each methyl, R3 and R4 are not each H, and when X is chlorine R1 is hydrogen and R2 is methyl and R3 and R4 are not each hydrogen.
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