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Antiarrhythmic 1-hydroxyphenyl-4,4-di:phenyl-1,3-butadiene derivs. - prepd. e.g. by alkaline hydrolysis of 4,4-di:phenyl-4,4a-di:hydro-pyrano benzopyran-3,10-di:one cpds.
Antiarrhythmic 1-hydroxyphenyl-4,4-di:phenyl-1,3-butadiene derivs. - prepd. e.g. by alkaline hydrolysis of 4,4-di:phenyl-4,4a-di:hydro-pyrano benzopyran-3,10-di:one cpds.
1-(Hydroxyphenyl)-4,4-diphenyl-1,3-butadiene derivs. are cpds. of formula (I) R1 is 1-4C alkyl 1-4C alkoxy, NO2 halogen, CF3 or H;R2 is H acetyl or benzoyl;R3 is H, halogen, NO2 or OCH3; and X is piperidino, morpholino, piperazino, 4-methyl-piperazino, 4-(2-hydroxyethyl)piperazino a gp. OR4 (in which R4 is H, acetyl or benzoul) or a gp. -NH-NHR5 (in which R5 is H, CH3, C2H5 or phenyl). (I) (and its intermediates) have cardiovascular, esp. antiarrhythmic activity. Daily dosage is 15-30 mg/kg. p.o. or 3-6 mg/kg parenterally.
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