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Process for the preparation of novel, antipsychotic-acting dibenzoxa zonin, dibenzoxazesin and dibenzoxazacycloone decane derivatives and corresponding other tide derivatives.
Process for the preparation of novel, antipsychotic-acting dibenzoxa zonin, dibenzoxazesin and dibenzoxazacycloone decane derivatives and corresponding other tide derivatives.
The present invention relates to new dibenzoxazonine, dibenz-oxazecine or dibenzo-oxaazacycloundecane derivatives and corresponding thia- and aza derivatives thereof, of the general formula I: IMAGE I or a pharmaceutically acceptable acid addition salt or nitrogen oxide thereof, in which X represents oxygen, sulphur or the group NR5, R5 is hydrogen or alkyl (1-4 C), R1, R2, R3, R4 each represent hydrogen, hydroxy, halogen, cyano, alkyl, alkoxy, aralkoxy, alkylthio, methylenedioxy, CF3, NO2, NH2, hydroxyalkyl or an acyloxy group, R represents hydrogen, alkyl, alkenyl or aralkyl, hydroxyalkyl or acyloxyalkyl and n represents the number 0, 1 or 2, having valuable C.N.S. properties.
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机译:本发明涉及通式I的新的二苯并恶唑啉,二苯并恶唑嗪或二苯并氧杂氮杂环十一烷衍生物及其相应的硫杂和氮杂衍生物或其药学上可接受的酸加成盐或氮氧化物,其中X代表氧,硫或基团NR5,R5是氢或烷基(1-4 C),R1,R2,R3,R4分别代表氢,羟基,卤素,氰基,烷基,烷氧基,芳烷氧基,烷硫基,亚甲二氧基,CF3, NO 2,NH 2,羟烷基或酰氧基,R代表氢,烷基,烯基或芳烷基,羟烷基或酰氧基烷基,n代表数字0、1或2,具有有价值的CNS属性。
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