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REESTABLISHMENT OF IFN-η INDUCIBILITY OR CONSTITUTIVE EXPRESSION OF MHC CLASS II IN TUMOR CELLS
REESTABLISHMENT OF IFN-η INDUCIBILITY OR CONSTITUTIVE EXPRESSION OF MHC CLASS II IN TUMOR CELLS
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机译:肿瘤细胞中IFN-η诱导性或MHC II类组成型表达的重建
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摘要
A process of producing a cancer vaccine against IFN-η noninducible-MHC-class II tumor cells with otherwise functional MHC class II genes and which are defective at a DNA sequence other than MHC class II genes. The process includes the steps of isolating IFN-η noninducible tumor cells and then transforming IFN-η noninducible tumor cells with a DNA sequence controlling the non-MHC class II defect. Once transformed, the cells are treated with IFN-η, if needed, and an effective amount of the cells or cell membranes administered to a patient to stimulate the patient's immune system against the tumor cells.
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