INHIBITION OF GENE OF PATHOLOGICAL SUBJECT EXPRESSED UNDER CONTROL OF TRANSCRIPTION FACTOR BY DOUBLE-STRANDED CYCLIC OLIGONUCLEOTIDE CONTAINING DNA BINDING SITE FOR THE TRANSCRIPTION FACTOR

摘要

PURPOSE: To provide a method for performing a treatment of various diseases by inhibiting the expression of cells, viral genes, tumor genes, etc., expressed under the control of a prescribed transcription gene with a double-stranded closed chain oligonucleotide containing a binding site for the transcription factor. ;CONSTITUTION: This inhibition of a gene of a pathological subject is to treat coronal arterial diseases, hepatitis B, a tumor, etc., by using a compound consisting of a double stranded closed oligonucleotide containing a binding site for a prescribed transcription factor consisting of a hepato-specific transcription factor(HNF-1), etc., i.e., by using a double-stranded cyclic oligonucleotide containing a DNA binding site for the prescribed transcription factor for inhibiting the expression of the prescribed gene such as a hepato specific gene such as fibrinogen, transthyretin and apolipoprotein B, a viral gene such as pre-S1 of hepatitis B, and a tumor gene of pathological subjects under the control of a promoter or an enhancer element capable of binding with the transcript ion factor.;COPYRIGHT: (C)1996,JPO