Process for the treatment of glomerulonephritis in a patient in need of this treatment article of manufacture hybridoma antibody 5g.1; 1 isolated nucleic acid protein isolated polypeptide vector recombinant host cell nucleic acid vector process to produce an isolated isolated anti-c5 antibody c5 polypeptide process to produce an isolated anti-c5 antibody protein isolated nucleic acid molecule process to produce an anti-c5 antibody anti-c5 antibody 5g46k fragment 5g27k peptide 5g325aa isolated peptide 5g200aa isolated oligopeptide isolated process to induce an animal to produce an anti- c5 process for identifying an anti-c5 antibody and process for treating a patient in need of complete inhibition

摘要

The present invention relates to an antibody characterised in that it comprises at least one antibody-antigen binding site, exhibits specific binding to human complement component C5, said specific binding being targeted to the alpha chain of human complement component C5, inhibits complement activation in a human body fluid and does not specifically bind to the human complement activation product free C5a, wherein the antibody binds specifically with (i) a fragment comprising amino acid residues 660-1019 of SEQ ID NO:2; (ii) a peptide comprising amino acid residues 725-1049 of SEQ ID NO:2; (iii) a peptide comprising amino acid residues 850-1049 of SEQ ID NO:2; or (iv) a peptide comprising the amino acid sequence of SEQ ID NO:1.