Recombinant hepatitis B virus DNA molecules, hosts transformed therewith, HBV antigen polypeptides, DNA sequences encoding the HBV antigen polypeptides, methods for the detection of hepatitis B virus antibodies, methods for producing said DNA molecules, to processes for the preparation of said polypeptides and means for detection of HBV infection

摘要

Recombinant DNA molecules and hosts transformed with them which produce polypeptides displaying HBV antigenicity and genes coding therefor and methods of making and using these molecules, hosts, genes and polypeptides. The recombinant DNA molecules of this invention are characterized by structural genes that code for at least one polypeptide displaying HBV antigenicity. In appropriate hosts these recombinant DNA molecules permit the production and identification of genes and polypeptides characteristic of HBV antigenicity and their use in compositions and methods for detecting HBV virus infections in humans and stimulating the production of antibodies against this infection.